Another study by Mantovani et al. [40] investigated the effect of L-carnitine 3 g/day for four months in 332 patients with advanced stage tumors at any site and cancer-related anorexia/cachexia syndrome on a wide array of functional and anatomic outcomes, including grip strength, QoL, serum levels of interleukin 6 (IL-6), tumor necrosis factor α (TNFα), ROS, Glasgow Prognostic Score (GPS), total daily physical activity, and performance status as secondary outcomes. This evidence concerns the gene TNF and cancer.