The reported age at which risk-reducing surgery is offered is later than the minimum age (35 years) for path_MLH1 and path_MSH2 carriers suggested by the recent expert consensus statement [6], which was based on the reported rapidly rising risk of gynecological cancers for path_MSH2 and path_MSH6 carriers from that age onwards [2]. The gene discussed is MSH6; the disease is female reproductive organ cancer.