We have shown that sera from subjects with low LCAT concentration, characterized by an increased unesterified/total cholesterol ratio and accumulation of discoidal preβ-HDL (Table S4), present with pro-oxidative effects on podocytes and tubular cells and impair podocin expression that may contribute to the onset and progression of renal dysfunction observed later in these subjects [32]. This evidence concerns the gene NPHS2 and Abnormal renal physiology.