Increasing evidence demonstrates an increase in the expression and/or activity of CD39 and CD73 in tumor endothelial cells as well as in immune cells (i.e., Treg cells, myeloid-derived suppressor cells (MDSCs), macrophages, DCs, and Th17 cells) isolated from patients with CRC [76,77,78,79,80]. This evidence concerns the gene ENTPD1 and colorectal carcinoma.