Similar results were reported in medical ICU patients with DM, including those with respiratory infections and septic shock, under intensive or conventional glycemic control with insulin: the lowest mortality occurred among patients with blood glucose levels between 3.9–5.5 mmol/L and increased consistently with blood glucose levels above this range, with the highest mortality at blood glucose levels ≥ 10 mmol/L [89]. The gene discussed is INS; the disease is diabetes mellitus.