Loss of PTEN, via suppressive effects on anaphase-promoting complex (APC) and its coactivator Cdh1-mediated ubiquitination, could stabilize 6-phosphofructo-1-kinase/fructose-2,6-biphosphatase isoform 3 (PFKFB3) family member [54] which is critical for the first commitment step of glycolysis and whose activity has been implicated in cancer [44]. The gene discussed is PTEN; the disease is cancer.