Generally, autophagy effects are context dependent to exert a tumor suppressive or oncogenic action; however, a very elegant study showed an association of a casein kinase 1 alpha 1 (CK1α)-dependent autophagic mechanism and the tumor-suppressor role exerted by PTEN/Atg7 signal in xenograft models as well as in lung cancers. The gene discussed is PTEN; the disease is neoplasm.