Specifically, the tumor suppressor activity of PTEN in the stroma is mediated by the regulation of multiple signaling pathways, such as Ras proto-oncogenes, Protein kinase B (PKB), also known as AKT and c-Jun N-terminal kinase (Jnk) networks, which modulate the transcription factor Ets2 and was able to reduce tumor growth and progression [13]. This evidence concerns the gene PTEN and neoplasm.