In line with these data, another study showed that miR-22-3p is a tumor suppressor in AML induced by PU.1, an important transcription factor of monocyte/macrophage differentiation, and reintroduction of miR-22-3p in AML blasts reversed the blocking of differentiation and the inhibition of cell growth [27]. The gene discussed is SPI1; the disease is acute myeloid leukemia.