Inhibition of the NOTCH1 pathway in ΔE-NOTCH1 T-leukemia samples was confirmed by Western blot, showing that in DBZ- vs. DMSO-treated cells, there was a strong downregulation in ICN1 protein levels, with Dtx1, a direct target of NOTCH1, also significantly decreased (Figure S2). This evidence concerns the gene NOTCH1 and leukemia.