Importantly, infiltration of human T-ALL cells in the peripheral blood, as assessed by flow cytometry analysis of human CD45-positive cells, was significantly reduced in mice injected with MOLT4 cells overexpressing miR-22-3p with respect to those injected with MOLT4 control cells (** p < 0.01; Figure 4D). The gene discussed is PTPRC; the disease is acute lymphoblastic leukemia.