For clarifying the properties of fibroinflammatory cytokines and their individual producing cells, many authors have successively demonstrated that IL-10 and IL-13 released from Th2, B lymphocyte-activating factor of TNF family (BAFF) and a proliferating inducing ligand (APRIL) released from M2-Mφ and PMN, IL-4 and IRF-7 released from pDC, IL-33 released from antigen presenting cell (APC) and endothelial cell (EC) in patients with IgG4-RD [117,118,119,120,121,122]. The gene discussed is TNFSF13; the disease is immunoglobulin G4-related sclerosing disease.