The CXCL12/CXCR4 axis also activates the EMT program in colorectal cancer, targeting the Wnt/β-catenin pathway [7,14,15,16], and in multiple carcinomas such as pancreatic cancer [17], ovarian cancer [18] and non-small cell lung cancer (NSCLC) [19]. Here, CXCR4 is linked to non-small cell lung carcinoma.