HMOX1 and obesity due to melanocortin 4 receptor deficiency: This is especially important in patients who are predisposed to “the perfect cytokine storm” from COVID-19, including those with the longer GT allele HO-1 polymorphism, abundant white adipose cells (in obesity and diabetes), and those with CYP2D6 polymorphisms that lead to supra- or sub-therapeutic drug levels.