Importantly, NF-kB (p50/p65) is rapidly induced by a large number of reactive-oxygen species (ROS)-inducing neurochemical and biophysical signals inducing those associated with viral and bacterial infections, ionizing radiation, cytokines and chemokines, Aβ42 peptides and hypoxia, and the neurogenetic coupling of the ROS-sensitive NF-kB (p50/p65) to the up-regulation of these NF-kB (p50/p65) sensitive miRNAs is a very tightly coupled and rapid genetic event (Hill et al., 2015 [30]; Alexandrov et al., 2019 [58]; Zhao and Lukiw 2018 [59]). The gene discussed is NFKB1; the disease is bacterial infectious disease.