Both miRNA-146a and miRNA-155 target the 3′ untranslated region (3′-UTR) of the complement factor H (CFH) mRNA in overlapping binding sites leading to a highly effective down-regulation in the expression of CFH and runaway loss-of-complement control, markedly increased pro-inflammatory signaling thereby contributing mechanistically to both AD and AMD inflammatory neuropathology (Hill et al., 2015 [30]; Fan et al., 2020 [68]). The gene discussed is CFH; the disease is Alzheimer disease.