KCNJ11 and cancer: Figure 5b shows that 10 of the proposed proteins are co-expressing (black lines) with the proteins in the HR pathway. All of the genes encoding for these proteins showed mRNA upregulation and amplification as their top genomic alterations in the oncoprint in Figure 3d. Gene amplifications can trigger the expression of genes in cancer cells, which could affect DNA repair and damage response [69,70], this could favor the upregulation of HR and BIR-related pathways in ALT+ tumors; nonetheless, further experimentation would be required to validate this statement.