As shown in Figure 4b, there are 24 genes shared between frequent and rare ALT tumors, and 50 genes are shared among the three groups; all 20 ALT-related genes (100%) proposed in this study are highly mutated in the PCA studies (Figure 3b) and included in the 50 genes list; according to these results, the frequency of alterations of ALT-related genes is distributed among all cancer types. The gene discussed is GPT; the disease is cancer.