GJB2 and hearing loss disorder: Shinagawa et al. (2020) confirmed the founder effect in origin of six GJB2 mutations frequently observed in Japanese hearing loss patients (c.235delC, p.Val37Ile, p.[Gly45Glu;Tyr136*], p.Arg143Trp, c.176_191del, and c.299_300delAT) and estimated the year at which each mutation occurred: c.235delC—around 6500 years ago, p.[Gly45Glu;Tyr136*]—around 6000 years ago, p.Arg143Trp—around 6500 years ago, c.176_191del—around 4000 years ago, c.299_300delAT—around 7700 years ago, and p.Val37Ile - around 14500 or 5000 years ago [39].