PTAFR and age: Age-associated inflammation in the lung is linked with increased senescence markers (e.g., p16 expression) and SASP (e.g., IL-1α/β, IL-6, TNF-α and CXCL1), which is coincident with an increased expression of S. pneumoniae cell-surface receptors keratin 10 (K10), laminin receptor (LR) and platelet-activating factor receptor (PAFr) [77].