BDNF and Anxiety: EGCG and glatiramer acetate can improve the expression of both brain-derived neurotrophic factor (BDNF) and beneficial cytokines in CNS [36], and promote an increase in HO-1 expression level [37], whereas, in MS patients, EGCG (800 mg/die, orally, for 4 months) plus coconut oil improved anxiety and disability by decreasing IL6 serum level [38].