Only one small molecule TLR7/8/9 antagonist, CPG-52364 developed by Coley Pharmaceutical Group was taken into phase 1 trial for systemic lupus erythematosus (SLE) but was discontinued in 2010 (https://clinicaltrials.gov/ct2/show/NCT00547014). The gene discussed is TLR7; the disease is systemic lupus erythematosus.