420 mg orally once daily dose for CLL.Serious TEAE: hemorrhage, hypertension, ventricular arrhythmias, atrial fibrillation, atrial flutter, decrease in blood cell counts and Tumor lysis syndrome.Invasive fungal infections and Hepatitis-B reactivation observed.Ibrutinib-induced autoimmune hemolytic anemia and rare nail plate abnormalities also seen [62]. This evidence concerns the gene PPIB and B-cell chronic lymphocytic leukemia.