TLR7/8/9 antagonists are mostly antisense oligonucleotide (ASO) like Bazlitoran (IMO-8400), which was granted orphan drug status [39] for diffuse large B cell lymphoma (DLBCL) and Waldenstrom’s Macroglobulinemia (WM). The gene discussed is TLR7; the disease is diffuse large B-cell lymphoma.