HSPB6 and Hyperglycemia: An in vivo functional study found that these HSP20-enriched EVs could ameliorate hyperglycemia-induced cardiac adverse remodeling by significantly improving the left ventricular internal diameter at end-diastole (LVIDd), the left ventricular ejection fraction (LVEF%), and the density of myocardial blood vessels in STZ-treated diabetic mice.