Functionally, molecular analysis of sciatic nerve tissues showed that SC-Exo treatment reversed diabetes-reduced miR-21, miR-27a, and miR-146a levels, as well as diabetes-increased Semaphorin 6A (SEMA6A), PTEN, and nuclear factor-κB (NF-κB) levels. This evidence concerns the gene NFKB1 and diabetes mellitus.