In another study, Zhao et al. [62] treated obese (induced by a high-fat diet) mice with EVs obtained from adipose-derived stem cells (ADSCs) and found that these EVs could polarize macrophages into anti-inflammatory type 2 macrophages (M2) phenotypes by an activation of signal transducer and activator of transcription 3 (STAT3) pathway, which consecutively upregulated arginase 1(ARG-1) expression in macrophage, thereby improving both the metabolic balance and insulin resistance in mice. Here, ARG1 is linked to Insulin resistance.