Stimulation with BMP2 was sufficient to induce a 2-fold increase in the levels of BRE-Luc reporter activity in OKF6 cells, while the addition of BMP2 had only a modest effect on the measured levels of BRE-Luc reporter activity in C666-1 cells, likely reflecting saturation of the BRE by the very high endogenous levels of activated pSmad1/5/8 in the NPC cell line. This evidence concerns the gene BMP2 and nasopharyngeal carcinoma.