Specifically, we will summarize the clinical manifestations of single nucleotide polymorphisms (SNPs) in the BARD1 gene and the expression of BARD1 isoforms in neuroblastoma (NB), gastrointestinal cancers, non-small cell lung cancer (NSCLC), nephroblastoma, Ewing sarcoma, and acute myeloid leukemia (AML). The gene discussed is BARD1; the disease is acute myeloid leukemia.