BARD1 expression was significantly associated with poor prognostic factors such as TNM stage III and IV, Barcelona clinic liver cancer (BCLC) stage B and C, tumor size greater than 5cm, HBV infection (positive HBV surface antigen, or HBsAg) and high serum AFP and aspartate aminotransferase (AST) concentrations. Here, BARD1 is linked to neoplasm.