We are reporting that in newly diagnosed CLL patients with the expression of the high-risk progression marker CD38 on leukemic cells, the chemokine receptors CCR1 and CCR2 were up-regulated on the PB CD19+CD5+ lymphocytes, indicating their increased migration capability toward chemokine-ligands secreting organs. The gene discussed is CD38; the disease is B-cell chronic lymphocytic leukemia.