Within our cohort of newly diagnosed CLL patients (n = 61), which included 39 patients with the CD38-expressing leukemic cells, we determined a positive correlation between expression of CD38 (the negative predictor of CLL progression) and expression of the chemokine receptors CCR1 and CCR2 on the PB CD19+CD5+ lymphocytes (rs = 0.50 and rs = 0.38, respectively). This evidence concerns the gene CD5 and B-cell chronic lymphocytic leukemia.