Alternative possible biomarkers in the form of growth factors, such as VEGF and its receptors, placental growth factor (PlGF), Interleukin-8 (IL-8), PD-1/PD-L1 expression, T-cell immunoglobulin and mucin domain 3 (TIM3), X-linked transcriptional regulator (ATRX), death domain-associated protein 6 (DAXX) genes, circulating tumour cells, and circulating tumour DNA, have been studied without consensus on their utility [148,149,150,151,152]. The gene discussed is CD274; the disease is neoplasm.