AGT and hypertensive disorder: Hypertension and cancer share a wide range of pathophysiological pathways: the increased activity of Angiotensin II (ANGII), vasopressin and catecholamines, alterations in calcium homeostasis, inflammation, high levels of ROS, disturbances in the levels and activity of growth factors, mainly angiogenic; all these factors could interplay in a vicious circle that reciprocally links cancer and hypertension [122].