Tumour-associated adipocytes act as an endocrine organ that induces: (I) tumour growth, producing a high concentration of tumour-promoting hormones, such as leptin and oestrogen and lowering the levels of tumour suppressor hormones, such as adiponectin, (II) enhanced tumour invasive capacity, by promoting local chronic inflammation through IL-6 secretion and (III) the establishment of a strict metabolic interaction based on the direct transfer of triglyceride-enhancing β-oxidation process and metastatic expansion [103,104,105]. This evidence concerns the gene LEP and neoplasm.