Prebiotics, particularly inulin and oligofructose, have been shown to increase Bifidobacterium, which has beneficial metabolic effects, such as reducing body fat, serum triglycerides, and the proinflammatory marker interleukin-6 (IL-6) in children with overweight or obesity [20]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.