COIL and infection: Then TIR-NB-LRR promoted enhanced disease susceptibility 1 (EDS1), which induced autophagy by resistant to P. syringae 4 (RPS4) under AvrRps4 infection; non-race specific disease resistance (NDR1) is required for a different R proteins called coiled-coil (CC)-NB-LRR (CC-NB-LRR), which was mediated by RPS2 under AvrRpt2 infection, and triggers HR independent of autophagy [6].