Since Oxt is involved in thermoregulation, which is essential in energy balance and in the etiology of obesity [44], we measured the mRNA levels of Oxt and Oxtr in brain, bone, and brown adipose tissue of mice exposed to short time 6 h (6 h) and 5 days (5 d) cold stress (CS). This evidence concerns the gene OXTR and obesity due to melanocortin 4 receptor deficiency.