NUP98 and acute myeloid leukemia: For example, upon expressing AML associated NUP98-HOXA9 (NA9) in Drosophila hematopoietic system, Baril et al. observed an increase in cell proliferation in addition to hyperplasia of the lymph gland, which was correlated with dysregulated signaling in Drosophila homologue of the mammalian FLT-4 signaling, PVR [88].