For example, upon expressing AML associated NUP98-HOXA9 (NA9) in Drosophila hematopoietic system, Baril et al. observed an increase in cell proliferation in addition to hyperplasia of the lymph gland, which was correlated with dysregulated signaling in Drosophila homologue of the mammalian FLT-4 signaling, PVR [88]. The gene discussed is HOXA9; the disease is acute myeloid leukemia.