The work reported here shows that AXT107, a 20-mer peptide that inhibits VEGF signaling and activates Tie2 though endogenously released Ang2 to help resolve underlying inflammation, could be used to treat DME, DR, RVO, AMD, uveitis, DED, and other ocular diseases that are inadequately treated with the current standard of care therapies. This evidence concerns the gene TEK and age-related macular degeneration.