ANGPT2 and Sepsis: In support of its pro-inflammatory role, increases in the levels of circulating Ang2 are proportional to the severity of their conditions [17,18], while the depletion or knockdown of Ang2 or conversion of Ang2 to a Tie2 agonist by an experimental antibody was found to reduce vascular leakage and improve survival in animal models of sepsis [19,20,21,22].