Regarding discordant lymph nodes, Schwenck et al. suggested that if a lymph node was exclusively detected by [68Ga]Ga-PSMA PET/CT, it could be due to better lesion contrast on this imaging modality; and when a lesion was only detected on [18F]Fluorocholine PET/CT, it could partly be explained by non-specific [18F]Fluorocholine uptake in inflammatory nodes or by the variable biological characteristics of prostate cancer with different transporters being expressed. This evidence concerns the gene FOLH1 and prostate cancer.