For instance, the circHIPK3/miR-124/miR-29b/COL1A1/COL4A1/CDK6 [16], ciRS-7/miR-7/PTEN/PI3K/AKT [18] and other signaling pathways (Table S11) may promote the onset, establishment and progression of the tumor by modulating the cell cycle progression, tumor growth, proliferation, apoptosis, invasion, migration, survival and radiosensitivity, stemness, epithelial–mesenchymal transition (EMT) and metastasis of malignant gastric cells. The gene discussed is PIK3CA; the disease is neoplasm.