MAPT and Alzheimer disease: Since several pieces of evidence suggested that liver steatosis may negatively affect cognitive performance in AD subjects, n3-PUFA supplementation can be considered as an option to improve NAFLD-related brain dysfunction, since these fatty acids are able to improve liver n3/n6 PUFA imbalance and modulate many neuronal functions, protecting them from oxidative stress and inhibiting signaling pathways responsible for tau phosphorylation in AD and dementia patients [80].