AD pathophysiology is characterized by a progressive neuronal loss, mainly at the cholinergic system, and two major hallmarks, intracellular neurofibrillary tangles (NFTs) [2], mainly composed of hyperphosphorylated tau protein (τ), and extracellular plaques constituted by amyloid-β peptide (Aβ) [3]. Here, MAPT is linked to Alzheimer disease.