TNFSF10 and triple-negative breast carcinoma: Remarkably, in the TRAIL resistant triple negative breast cancer cell line MDA-MB-231, the TRAIL-induced apoptosis enhancing activity of all these marine-derived secondary metabolites was particularly obvious, given that in these cells, for a 6 hour stimulation time, apoptosis induced by single agents alone was low, whereas combined treatments induced strong apoptosis ranging from 30 to almost 80% (Figure 5C).