Ang II-induced and catalytically active (responsive to β-aminopropionitrile (BAPN) inhibition) LOX was also reported to contribute to vascular stiffening and arterial hypertension in vivo in mice [14], and to accelerate cardiac remodeling and hypertrophy in a mouse model with elevated expression of LOX in cardiomyocytes and cardiofibroblasts [15]. This evidence concerns the gene LOX and Hypertension.