In a murine model of angiotensin II (Ang II)-induced abdominal aortic aneurysm (AAA), genome-wide transcriptional profiling studies identified LOX, together with ADAM17 and epidermal growth factor receptor (EGFR), as highly ranked gene subnetworks [9], and localized LOX within vascular smooth muscle cell (VSCM) caveolae [10]. Here, AGT is linked to triple-A syndrome.