In a highly tumorigenic subpopulation of hepatocellular carcinoma containing tumor-initiating, sphere-forming cells that generate tumors with vascular enrichment, the upregulation of LOX correlated with an increase in secreted VEGF that promoted tube formation of endothelial cells, an effect that was blocked by BAPN, demonstrating the pivotal role of LOX in these cells [30]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.