Altered LOX expression and functions have been associated with vascular, cardiac, pulmonary, dermal, placenta, diaphragm, kidney and pelvic floor disorders, glioblastoma, diabetic neovascularization, osteogenic differentiation and bone matrix formation, ligament remodeling, polycystic ovary syndrome, fetal membrane rupture and stages of tumor progression and metastasis in various cancer types. This evidence concerns the gene LOX and neoplasm.