Similarly, the pro-inflammatory Interferon gamma (IFN-γ), active in aortic aneurysm, and arteriosclerotic plaque rupture, were demonstrated to reduce LOX mRNA and activity in rat aortic smooth muscle cells, partly via transcriptional downregulation, and also by reducing the LOX mRNA half-life [71]. The gene discussed is IFNG; the disease is aortic aneurysm.