The Ang II-stimulated hypertensive mice overexpressing active LOX accompanied by increased H2O2 (the byproduct of the catalytic reaction of LOX with its substrates) showed both increased vascular stiffness and oxidative stress that promoted p38MAPK activation as part of the signaling pathway involved in hypertension-associated vascular remodeling [16]. The gene discussed is LOX; the disease is Hypertension.