CCl4-induced liver fibrosis was decreased in MR1−/− mice, while both CCl4-induced and bile duct ligation-induced liver fibrosis were exacerbated in Vα19 TCR transgenic mice with enhanced MAIT cell generation, demonstrating a profibrotic role of MAIT cells in liver fibrosis [76]. This evidence concerns the gene MR1 and Hepatic fibrosis.