In 2-OA-BSA-induced autoimmune cholangitis mice, activation of iNKT cells by α-Galcer treatment promoted lymphocyte infiltration and collagen deposition in the liver, which was ameliorated in CD1-deficient mice, indicating a profibrotic role of iNKT cells in primary biliary cholangitis (PBC) [71]. Here, CD1C is linked to primary biliary cholangitis.