MAPK8 and plexiform neurofibroma: Calebin A has been shown to exert anti-inflammatory and anti-tumor properties by the induction of apoptosis and modulating different signaling pathways [e.g., mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), p38, Jun N-terminal kinase (JNK)] in gastric cancer and neurofibroma [38,39].