In contrast, Calebin A in the multicellular pro-inflammatory TME cultures inhibited distinctly nuclear staining and nuclear translocation of p65-NF-κB in CRC cells in a dose-dependent fashion by around 71% and 84% (Calebin A 1, 5 μM) compared to the control TME cultures (Figure 4). Here, NFKB1 is linked to colorectal carcinoma.