Although most infections are light, with clinical signs such as fever, pulmonary congestion and eosinophilia, in heavy infections some people develop lymphadenopathy, granulomatous hepatitis, nephritis, and arthritis, elevation of serum immunoglobulin E (IgE)concentration, presence of allergen-specific IgE, asthma and promotion of pulmonary fibrosis [8]. The gene discussed is IGHE; the disease is asthma.