Using array-comparative genomic hybridization (a-CGH), Frye and colleagues subsequently demonstrated that, in a panel of breast cancer cell lines, 18 out of 50 cell lines analyzed had a copy number gain of the genomic region containing NSUN2 (5p15.31-33), and of these, 16 (16/18) were found to have significantly increased expression of NSUN2 [95]. The gene discussed is NSUN2; the disease is breast cancer.