Given the known roles of HMGA2 in inducing epithelial-to-mesenchymal transition (EMT) and in contributing to colon cancer progression [101,102,103], the authors subsequently went on to show that the circSUN2/IGF2BP2 complex bound to HMGA2 mRNA in an RNA–protein ternary complex that stabilizes HMGA2 mRNA and results in the promotion of EMT in CRC cells [100]. This evidence concerns the gene HMGA2 and malignant colon neoplasm.