Alternatively, it may be possible to target NSUN2-mediated events such as that shown for the lncRNA NMR in esophageal cancer, whereby NSUN2-methylated NMR interacts with the chromatin remodeling factor Bromodomain PHD Finger Transcription Factor (BPTF) [35,118] to regulate resistance to cisplatin. This evidence concerns the gene NSUN2 and esophageal cancer.