SMAD7 and Cowden disease: Consistently, a phase 1 study conducted showed that oral administration a Smad7 AS-containing oral drug, denominated Mongersen (previously termed GED-0301) in active CD patients was safe and associated with clinical benefit, and later on, two distinct phase 2 studies confirmed the safety of the drug and showed that Mongersen induced clinical and endoscopic improvement in steroid-dependent and/or resistant CD patients [9,10,11].