Both miR526b and miR655 expression in breast tumors is positively and significantly correlated with HIF-1α expression in the set of tumor samples we used in this study and also data extracted from The Cancer Genome Atlas (TCGA) cBioPortal database, which includes data from 16 different breast cancer studies, strongly suggesting that hypoxia and miRNAs collaborate to promote breast cancer progression. The gene discussed is HIF1A; the disease is breast carcinoma.