TOX and cancer: The final phase of cancer immunoediting, the escape phase, is enabled by the genomic instability of cancer cells, activation of oncogenes, downregulation of tumor suppressor genes, ectopic reactivation of developmental/cancer testis/meiosis genes, deregulation of JAK/STAT signaling, further upregulation of TOX, contribution of external disease triggers/promoters (e.g., S. aureus enterotoxins), and Darwinian pressure by the immune system [28,32,56,57,58,59,60,61,62] (Figure 2C).