NLRP3 and psoriasis: TCLPA5 administration-attenuated immunoreactivities of both F4/80 (Figure 3a,b) and NLRP3 (Figure 4a,b), along with LPA5 upregulation in infiltrated macrophages (Figure 3c), collectively suggest that LPA5 could regulate NLRP3 inflammasome activation in macrophage to induce inflammatory responses in psoriasis.