CA9 and neoplasm: Its localization at fibrotic sites and areas of pancreatitis, the ability to be induced in both a hypoxia-dependent and independent manner, the existence of crosstalk between CAIX and inflammatory molecules, as well as its correlation with necrosis, tumor grade, and poor prognosis [25] places CAIX in the center of pathological events leading from malignant transformation to pancreatic cancer progression and metastasis.