Considering the physiopathology of potassium homeostasis, it is not surprising that advanced age, chronic kidney disease (CKD), chronic heart failure (CHF), diabetes, use of RAASi (such as ACE-inhibitors-ACEi and angiotensin receptor blockers-ARB) and mineralocorticoid receptor blockers (MRA) constitute the main risk factors in the development of hyperkalemia [9]. The gene discussed is ACE; the disease is congestive heart failure.