Immunofluorescence analyses demonstrated co-localization of CX43 and ZO-1 with (P)RR in TM tissues from POAG (Figure 2C–H) and NVG (Figure 2I–N) eyes, supporting the upregulation of CX43 and ZO-1 expression via (P)RR signaling pathway in TM cells. This evidence concerns the gene TJP1 and open-angle glaucoma.