Double-staining results showed co-localization of (P)RR with prorenin (Figure 1C–E, I–K) and AT1R with AGT (Figure 1F–H, L–N) in TM tissues from POAG (Figure 1C–H) and NVG (Figure 1I–N) eyes. The gene discussed is AGTR1; the disease is open-angle glaucoma.