inflammasomes are indispensable mediators of the innate immune response to infection [13]; they are constituted of large multimeric intracellular complexes that are capable of controlling activation of the proteolytic enzyme caspase-1 [13], which in turn regulates the proteolytic maturation of Interleukin-1β (IL-1β) and Interleukin-18 (IL-18), as well as a rapid, noxious, inflammatory form of cell death termed pyroptosis through cleavage of gasdermin D (GSDMD) [14,15]. The gene discussed is IL18; the disease is infection.