Some studies showed that among the myriad of cytokines evaluated in the MPN, could be prognostic for patients [64], such us IL-1 β which mediates inflammation both at tissue and systemic level; IL-6 that induces the activation of JAK/STAT pathway; IL-8 that influences the tumor microenvironment by retrieving MDSCs; VEGF which promotes angiogenesis; TGF-β which in primary myelofibrosis is associated with bone marrow fibrosis. This evidence concerns the gene IL6 and primary myelofibrosis.