The main population of TAMs comprises CD163+ M2 macrophages, and CD163+ TAMs release soluble (s)CD163 and several proinflammatory chemokines (CXCL5, CXCL10, CCL19, etc.)as a result of TAM activation to induce an immunosuppressive tumor microenvironment together with other immunosuppressive cells. Here, CXCL10 is linked to neoplasm.