IFNB1 and melanoma: In another report, intratumoral injection of IFN-b also increased CD8+ TILs in melanoma by the induction of M1 macrophage-related chemokines (CXCL9, CXCL10, CXCL11), leading to enhancement of the anti-tumor effects of anti-PD1 Abs for melanoma in vivo [17,66].