For example, Chen et al. established the hyperuricemia mouse model by PO for 14 days, and the expression of ABCG2 was upregulated in the model group [27], however, Kodithuwakku et al. established the hyperuricemia mouse model by PO for 7 days, and the expression of ABCG2 was downregulated in the model group [32]. The gene discussed is ABCG2; the disease is hyperuricemia.