In addition, the expression levels of urate transporters GLUT9 and URAT1 were upregulated from the 3rd day, while urate transporters ABCG2 and OAT1 were downregulated from the 3rd day, and NPT1 were down regulated from the 7th day in hyperuricemia mice kidney. This evidence concerns the gene SLC22A12 and hyperuricemia.