In this study, we analyzed age-related changes of STEP46 and STEP61 expression and activity in the retina of OXYS rats at the age of 20 days (the preclinical assay of AMD-like retinopathy) and at age 13 months (assessment of the progressive stage of disease) using age-matched Wistar rats as a control. The gene discussed is PTPN5; the disease is retinal disorder.