Meanwhile, several combination immunotherapy trials are ongoing, for example, a combination of a PD-L1 inhibitor (durvalumab) and an agonist of the co-stimulatory immune checkpoint OX40 (NCT02221960), with the aim to achieve a synergistic anti-tumor immune reaction in recurrent or metastatic solid tumors. The gene discussed is TNFRSF4; the disease is neoplasm.