Since the vaccination with BVAC-K1117 dramatically induced IFN-γ expression on tumor-infiltrating CD8 T cells (Figure S5A–C) and the IFN-γ produced by tumor-infiltrating CD8 T cells is a potential inducer of PD-L1 expression on tumor cells [39], we hypothesized that IFN-γ-dependent induction of PD-L1 expression on tumor cells contributed to the additive anti-tumor effect of anti-PD-L1 in BVAC-K1117 vaccinated mice. This evidence concerns the gene CD8A and neoplasm.