Given that the degree of homology between human and mouse HER2 is extremely high (88% identical to each other) [58] and that vaccination with human HER2 antigen, K684, expressing DC vaccine induced mouse tumor models in our previous study [59], we speculate that the normal tissue damage induced by BVAC-HER2 vaccination might be minimal even in HER2+ cancer patients. The gene discussed is ERBB2; the disease is neoplasm.