Although the IFN-γ production in tumor-infiltrating CD8 T cells was considerably increased by BVAC-K1117 vaccination compared to without vaccination or Bmo/aGC vaccination, PD-L1 expression on tumor cells was not significantly changed by the BVAC-K1117 vaccination (Figure S5D,E), suggesting that enhanced anti-tumor effect by the addition of anti-PD-L1 was not due to IFN-γ-dependent induction of PD-L1 expression on tumor cells by BVAC-K1117 vaccination. The gene discussed is CD274; the disease is neoplasm.